Evaluation Of Serum Antioxidant Vitamins Among Protein Energy Malnourished Children In Sokoto, Northern Nigeria.
Department of Chemical Pathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto.
Akuyam S.A, Yeldu M .H.
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto.
Department of Paediatrics Usmanu Danfodiyo Teaching Hospital, Sokoto.
Department of Biochemistry Usmanu Danfodiyo University, Sokoto.
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Background and aim: Protein energy malnutrition is a major public health problem in the tropical and sub tropical regions of the world. Deficiencies of micronutrients, macronutrients and weight loss have also been demonstrated in cases of PEM. There is
paucity of data in the pattern of serum antioxidant vitamins in PEM children in Sokoto, northern
Nigeria. The aim of the present study was to evaluate serum antioxidant vitamins among children with PEM in Sokoto. Materials and Methods: This study evaluated the antioxidants vitamins and other biochemical and anthropometric parameters among 106 children with protein energy malnutrition and 106 age- and sex- matched apparently healthy subjects (controls).Participants were evaluated in the Departments of Chemical pathology and Paediatrics of Usmanu Danfodiyo University Teaching Hospitals
Result: The results of serum antioxidant vitamins among children with protein energy malnutrition and age- and sex–matched controls showed that concentrations of serum antioxidant vitamins A, C and E were significantly lower than the corresponding results among controls (p<0.001). Serum levels of plasma glucose, total protein and albumin among children with PEM were significantly lower than the controls (p<0.001). The results of the anthropometric parameters of PEM children showed significantly lower values than those of control children (p<0.001), while the BMI results showed no significant difference between the PEM children and control group (p>0.05). There was no correlation between the antioxidant vitamins and other biochemical parameters between the PEM children and control group.
Conclusion: It could be concluded that there are lower levels of the antioxidant vitamins in PEM children irrespective of their age and also their biochemical and anthropometric parameters were also low when compared with control group. It could be recommended that routine evaluation of the antioxidant vitamins shall be included in the management of patients with PEM in Nigerian Hospitals. This could reduce the morbidity and mortality in the affected children.