Pattern of Thyroid Binding Globulin Changes in the Three Stages Of Pregnancy in Port-Harcourt, Rivers State, Nigeria.

Ezeiruaku F.C
Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University Wilberforce Island, Bayelsa State.
Ukaji D.C.
Department of Medical Microbiology; Faculty of Medical Laboratory Sciences Madonna University, Elele, Rivers State.
Eze E.M
Transparent Earth Nig Limited, Kings Plaza, 11b Benjamin Opara treet, GRA Port Harcourt, Rivers State , Nigeria. 
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Correct diagnosis and treatment of thyroid dysfunction is Important to prevent both maternal and fatal complications. Common thyroid diseases have a strong predominance in women of child bearing age. For this reason, assessment of thyroid function during pregnancy is common, since normal physiological changes in pregnancy can make the interpretation of test for thyroid diseases difficult. The purpose of this study was to assess the normal changes in thyroxine binding globulin that occur during pregnancy and what laboratory test should be utilized to diagnose diseases during pregnancy. A total of 479 female adults were examined in this study of which 150 of them formed the control subjects (non pregnant women) and 329 formed the study subjects (pregnant women). Out of the 329 study subjects, 130 of them were in their first trimester, 113 in the second trimester, and 86 of them in the third stage of their pregnancy. The method of enzyme linked immunosorbent assay (ELISA) was used in carrying out the thyroid binding globulin quantitation. From the result obtained, the control group had mean ± SD value of 18.64 ± 4.92ug/l while the 1st, 2nd and 3rd trimesters of the study subjects had values of 24.43 ± 6.94 ug/l, 37.01 ± 10.20 ug/l and 35.51 ± 13.97ug/l respectively and this gave a normal range of 13.72 – 23.54ug/l for non pregnant group and 17.49 – 31.37 ug/L, 26.81 – 47.21 ug/L and 21.54 – 49.48 ug/L respectively for the 1st, 2ndand 3rd trimesters. The analysis showed a steadily increase (r = 0.0045) in the serum levels of TBG until about the week 32 when it remained steadily high. The analysis in the three stages showed a significant (P<0.05) difference in the mean values obtained with respect to the control group.

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